This can depend on a variety of things such as time of year, time of evening, telescope focal length, camera chip size and how much light pollution from the moon, street lights, etc. DSOs generally fall into two categories and each category has two sub categories. Firstly DSOs are either fairly big or fairly small, the big ones are more suited for short focal length telescopes and large chip cameras and the small ones are more suited to long focal length telescopes and small chip cameras, the exception to this is where you want to zoom into a small area of a large DSO or where you wanrt to show a small DSO in relation to its surroundings, but generally you will choose your target depending on what camera/scope combination you are using at the time. The next thing to consider is how much light pollution there is from the moon and the lights, if there is a full moon and other light pollution the traditional RGB imaging will be difficult and like me you will do narrow band imaging which rules out reflection nebula, star clusters and galaxies (unless you are adding a Ha channel to augment the red and blue channels). I tend to do over 90% of my imaging in narrow band so I will be choosing either emission nebulae, SNRs or PNs.
Providing the subject is visible from where I am imaging I will click on it in The Sky 6 software and click slew, the Paramount will then slew to point at my choice and because of the pointing accuracy it will be somewhere close to the middle of the chip